A novel atheroprotective role of MF59-like adjuvant when co-administered with CETP vaccine in rabbit model of atherosclerosis

نویسندگان

  • Ali Badiee Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Khalil Abnous Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Afshar Department of Anatomy, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran|Medical Toxicology Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran
  • Saeed Nazemi Research and Education Department, Razavi Hospital, Mashhad, Iran
  • Tamara Aghebati Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده مقاله:

Objective(s): In this study, for the first time, MF59 adjuvant was used to develop a cholesteryl ester transfer protein (CETP) vaccine. The efficacy of the vaccine was compared with the efficacy of CETP vaccine formulated with Alum/CpG, the formulation that its immunogenicity has been already demonstrated in rabbit and mice. Materials and Methods: Tetanus toxoid- CETP peptide (TT-CETP) was mixed with Alum/CpG or MF59-like and administered subcutaneously for total five times in rabbit model of atherosclerosis. Anti-TT-CETP specific antibody, CETP activity in sera and mRNA level of cytokine IL-4 and IFN-γ in peripheral mononuclear cells were determined. Therapeutic response was also examined by tracking serum lipoprotein levels and pathologic observation of atherosclerotic lesions at aortic site. Results: More anti-TT-CETP antibody was found in Alum/CpG vaccinated rabbits compared to buffer (P

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a novel atheroprotective role of mf59-like adjuvant when co-administered with cetp vaccine in rabbit model of atherosclerosis

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عنوان ژورنال

دوره 19  شماره 12

صفحات  1345- 1352

تاریخ انتشار 2016-12-01

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